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Diazepam is used in the treatment of anxiety disorders and for short-term relief of the symptoms of anxiety. It belongs to a class of drugs known as benzodiazepines.

Diazepam is also used to relieve the symptoms of acute alcohol withdrawal, to relax muscles, to relieve the uncontrolled muscle movements caused by cerebral palsy and paralysis of the lower body and limbs, to control involuntary movement of the hands (athetosis), to relax tight, aching muscles, and, along with other medications, to treat convulsive disorders such as epilepsy.

 

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Most important fact about Diazepam

Diazepam can be habit-forming or addictive. You may experience withdrawal symptoms if you stop using this drug abruptly. Discontinue or change your dose only on your doctor's advice.

How should you take Diazepam ?

Take dDiazepam exactly as prescribed. If you are taking diazepam for epilepsy, make sure you take it every day at the same time.

If you miss a dose of Diazepam

Take Diazepam as soon as you remember if it is within an hour or so of the scheduled time. If you do not remember until later, skip the dose you missed and go back to your regular schedule. Never take 2 doses at the same time.

Storage instructions for Diazepam

Store Diazepam away from heat, light, and moisture.

What side effects may occur when taking Diazepam ?

Side effects Diazepam cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Diazepam.

More common side effects of Diazepam may include:

Anxiety, drowsiness, fatigue, light-headedness, loss of muscle coordination

Side effects due to a rapid decrease in dose or abrupt withdrawal from Diazepam:

Abdominal and muscle cramps, convulsions, sweating, tremors, vomiting

Why should Diazepam not be prescribed ?

If you are sensitive to or have ever had an allergic reaction to Diazepam, you should not take Diazepam.

Do not take Diazepam if you have the eye condition known as acute narrow-angle glaucoma.

Anxiety or tension related to everyday stress usually does not require treatment with such a powerful drug as Diazepam. Discuss your symptoms thoroughly with your doctor.

Diazepam should not be prescribed if you are being treated for mental disorders more serious than anxiety.

Special warnings about Diazepam

Diazepam may cause you to become drowsy or less alert; therefore, you should not drive or operate dangerous machinery or participate in any hazardous activity that requires full mental alertness until you know how this drug affects you.

Anxiety or tension related to everyday stress usually does not require treatment with such a powerful drug as Diazepam. Discuss your symptoms thoroughly with your doctor.

Diazepam should not be prescribed if you are being treated for mental disorders more serious than anxiety.

If you have liver or kidney problems, use Diazepam cautiously.

Possible food and drug interactions when taking Diazepam

diazepam slows down the central nervous system and may intensify the effects of alcohol. Do not drink alcohol while taking this medication.

If Diazepam is taken with certain other drugs, the effects of either could be increased, decreased, or altered.

It is especially important to check with your doctor before combining Diazepam with any of the following:

Antiseizure drugs such as Dilantin
Antidepressant drugs such as Elavil and Prozac
Antipsychotic drugs such as Mellaril and chlorpromazine
Barbiturates such as phenobarbital
Cimetidine (Tagamet)
Digoxin (Lanoxin)
Disulfiram (Antabuse)
Fluoxetine (Prozac)
Isoniazid (Rifamate)
Levodopa (Larodopa, Sinemet)
MAO inhibitors (antidepressant drugs such as Nardil)
Narcotics such as Percocet
Omeprazole (Prilosec)
Oral contraceptives
Propoxyphene (Darvon)
Ranitidine (Zantac)
Rifampin (Rifadin)

Special information on Diazepam if you are pregnant or breastfeeding

Do not take Diazepam if you are pregnant or planning to become pregnant. There is an increased risk of birth defects.

If Diazepam is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished.

Recommended dosage of Diazepam

ADULTS

Treatment of Anxiety Disorders and Short-Term Relief of the Symptoms of Anxiety

The usual dose, depending upon severity of symptoms, is 2 milligrams to 10 milligrams 2 to 4 times daily.

Acute Alcohol Withdrawal

The usual dose is 10 milligrams 3 or 4 times during the first 24 hours, then 5 milligrams 3 or 4 times daily as needed.

Relief of Muscle Spasm

The usual dose is 2 milligrams to 10 milligrams 3 or 4 times daily.

Convulsive Disorders

The usual dose is 2 milligrams to 10 milligrams 2 to 4 times daily.

CHILDREN

Diazepam should not be given to children under 6 months of age.

The usual starting dose for children over 6 months is 1 to 2.5 milligrams 3 or 4 times a day. Your doctor may increase the dosage gradually if needed.

OLDER ADULTS

The usual dosage of Diazepam is 2 milligrams to 2.5 milligrams once or twice a day, which your doctor will increase as needed. Your doctor will limit the dosage to the smallest effective amount because older people are more apt to become oversedated or uncoordinated.

Overdosage of Diazepam

Any medication taken in excess can have serious consequences. If you suspect an overdose with Diazepam, seek medical attention immediately.

Symptoms of Diazepam overdose may include:

Coma, confusion, diminished reflexes, sleepiness


Recreational and illicit use of Diazepam

Diazepam is a drug of potential dependence and addiction. Between 50 and 64% of rats will self administer diazepam. Benzodiazepines including diazepam in animal studies have been shown to increase reward seeking behaviours by increasing impulsivity which may suggest an increased risk of addictive behavioural patterns with usage of diazepam or other benzodiazepines.

Diazepam has been found as an adulterant in heroin. This may be because diazepam greatly amplifies the effects of opioids.

Sometimes diazepam is used by stimulant users to 'come down' and sleep and to help control the urge to binge.

Benzodiazepines, including diazepam, nitrazepam and flunitrazepam account for the largest volume of forged drug prescriptions in Sweden, a total of 52% of drug forgeries being for benzodiazepines.

Diazepam was detected in 26% of cases of people suspected of driving under the influence of drugs in Sweden and its active metabolite nordazepam was detected in 28% of cases.

Other benzodiazepines and zolpidem and zopiclone also were found in high numbers. Many drivers had blood levels far exceeding the therapeutic dose range suggesting a high degree of abuse potential for benzodiazepines and zolpidem and zopiclone.

In Northern Ireland in cases where drugs were detected in samples from impaired drivers who were not impaired by alcohol, benzodiazepines were found to be present in 87% of cases. Diazepam was the most commonly detected benzodiazepine.

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