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Metronidazole is an antibacterial drug prescribed for certain vaginal and urinary tract infections in men and women; amebic dysentery and liver abscess; and infections of the abdomen, skin, bones and joints, brain, lungs, and heart caused by certain bacteria

Brand name: Flagyl

Generic Name: Metronidazole

 

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Most important fact about Metronidazole

Do not drink alcoholic beverages while taking Metronidazole. The combination can cause abdominal cramps, nausea, vomiting, headaches, and flushing. It can also change the taste of the alcoholic beverage. When you have stopped taking Metronidazole, wait at least 72 hours (3 days) before consuming any alcohol. Also avoid over-the-counter medications containing alcohol, such as certain cough and cold products.

How should you take Metronidazole ?

Metronidazole works best when there is a constant amount in the blood. Take your doses at evenly spaced intervals, day and night, and try to avoid missing any. If you are being treated for the sexually transmitted genital infection called trichomoniasis, your doctor may want to treat your partner at the same time, even if there are no symptoms. Try to avoid sexual intercourse until the infection is cured. If you do have sex, use a condom.

Metronidazole can be taken with or without food. It may cause dry mouth. Hard candy, chewing gum, or bits of ice can help to relieve the problem.

If you miss a dose of Metronidazole

Take Metronidazole as soon as you remember. If it is almost time for your next dose skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.

Storage instructions for Metronidazole

Store at room temperature. Protect from light.

What side effects when taking Metronidazole may occur ?

Side effects of Metronidazole cannot be anticipated. If any develop or change in intensity, tell your doctor immediately. Only your doctor can determine whether it is safe for you to continue taking Metronidazole.

Two serious side effects that have occurred with Metronidazole are seizures and numbness or tingling in the arms, legs, hands, and feet. If you experience either of these symptoms, stop taking Metronidazole and call your doctor immediately.

More common side effects when taking Metronidazole may include:

Abdominal cramps, constipation, diarrhea, headache, loss of appetite, nausea, upset stomach, vomiting

Less common side effects when taking Metronidazole may include:

Blood disorders, confusion, dark urine, decreased sex drive, depression, difficulty sleeping, dizziness, dry mouth (or vagina or vulva), fever, flushing, furry tongue, hives, inability to hold urine, increased production of pale urine, inflamed mouth or tongue, inflammation of the rectum, irritability, lack of muscle coordination, metallic taste, occasional joint pain, pain during sexual intercourse, painful or difficult urination, pelvic pressure, rash, stuffy nose, vertigo, weakness, yeast infection (candida) in vagina.

Why should Metronidazole not be prescribed ?

Metronidazole should not be used during the first 3 months of pregnancy to treat vaginal infections. Do not take Metronidazole if you have ever had an allergic reaction to or are sensitive to metronidazole or similar drugs. Tell your doctor about any drug reactions you have experienced.

Special warnings about Metronidazole

If you experience seizures or numbness or tingling in your arms, legs, hands, or feet, remember that you should stop taking Metronidazole and call your doctor immediately.

If you have liver disease, make sure the doctor is aware of it. Metronidazole should be used with caution.

Active or undiagnosed yeast infections may appear or worsen when you take Metronidazole.

Possible food and drug interactions when taking Metronidazole

Do not drink alcohol while taking Metronidazole and for at least 72 hours after your last dose.

If Metronidazole is taken with certain other drugs, the effects of either could be increased, decreased, or altered.

It is especially important to check with your doctor before combining Metronidazole with any of the following:

Blood thinners such as Coumadin

Cholestyramine (Questran)

Cimetidine (Tagamet)

Disulfiram (Antabuse)

Lithium (Eskalith)

Phenobarbital

Phenytoin (Dilantin)

Special information on Metronidazole if you are pregnant or breastfeeding

The effects of Metronidazole in pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, notify your doctor. Metronidazole should be used during pregnancy only if it is clearly needed. Metronidazole appears in breast milk and could affect a nursing infant. If Metronidazole is essential to your health, your doctor may advise you to stop breastfeeding until your treatment of Metronidazole finished.

Recommended dosages for Metronidazole

ADULT

Trichomoniasis

One-day treatment: 2 grams of Metronidazole, taken as a single dose or divided into 2 doses (1 gram each) taken in the same day.

Seven-day course of treatment: 250 milligrams 3 times daily for 7 consecutive days.

Acute Intestinal Amebiasis (Acute Amebic Dysentery)

The usual dose is 750 milligrams taken by mouth 3 times daily for 5 to 10 days.

Amebic Liver Abscess

The usual dose is 500 milligrams or 750 milligrams taken by mouth 3 times daily for 5 to 10 days.

Anaerobic Bacterial Infections

The usual adult oral dosage is 7.5 milligrams per 2.2 pounds of body weight every 6 hours.

CHILDREN

Amebiasis

The usual dose is 35 to 50 milligrams for each 2.2 pounds of body weight per day, divided into 3 doses taken for 10 days.

The safety and efficacy of Metronidazole for any other condition in children have not been established.

OLDER ADULTS

Your doctor will test to see how much Metronidazole is in your blood and will adjust your dosage if necessary.

Overdosage with Metronidazole

Any medication taken in excess can have serious consequences. If you suspect an overdose of Metronidazole, seek medical treatment immediately.

Symptoms of Metronidazole overdose may include:

Lack of muscle coordination, nausea, vomiting

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