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Paroxetine relieves a variety of emotional problems. It can be prescribed for serious, continuing depression that interferes with your ability to function. Symptoms of this type of depression often include changes in appetite and sleep patterns, a persistent low mood, loss of interest in people and activities, decreased sex drive, feelings of guilt or worthlessness, suicidal thoughts, difficulty concentrating, and slowed thinking. Paroxetine is also used to treat obsessive-compulsive disorder (OCD), a disease marked by unwanted, but stubbornly persistent thoughts, or unreasonable rituals you feel compelled to repeat. In addition, Paroxetine is prescribed for panic disorder, a crippling emotional problem characterized by sudden attacks of at least four of the following symptoms: palpitations, sweating, shaking, numbness, chills or hot flashes, shortness of breath, a feeling of choking, chest pain, nausea or abdominal distress, dizziness or faintness, feelings of unreality or detachment, fear of losing control, or fear of dying. Paroxetine can be prescribed for generalized anxiety disorder, a disease marked by excessive anxiety and worry that persists for at least 6 months and can't be easily controlled. True cases of generalized anxiety disorder are accompanied by at least three of the following symptoms: restlessness or a keyed-up or on-edge feeling, a tendency to tire easily, difficulty concentrating or spells when the mind goes blank, irritability, muscle tension, or sleep disturbance. Paroxetine can be used in the treatment of social anxiety disorder (also known as social phobia), a condition marked by shyness or stage fright so intense that it interferes with an individual's work and social life. Paroxetine is also prescribed for post-traumatic stress disorder, a crippling condition that sometimes develops in reaction to a disastrous or horrifying experience. Symptoms, which stubbornly refuse to abate, include unwanted memories and dreams, intense distress when confronted with reminders of the event, a general numbing of interest and enjoyment, jumpiness, irritability, poor sleep, and loss of concentration. Paroxetine CR, the controlled-release version, is prescribed for major depression, panic disorder, social anxiety disorder, and severe premenstrual symptoms classified as premenstrual dysphoric disorder. Paroxetine belongs to the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). Serotonin is one of the chemical messengers believed to govern moods. Ordinarily, it is quickly reabsorbed after its release at the junctures between nerves. Reuptake inhibitors such as Paroxetine slow this process, thereby boosting the levels of serotonin available in the brain. Brand name: Paxil
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Most important fact about Paroxetine Your symptoms may seem to improve within 1 to 4 weeks after beginning treatment with Paroxetine. Even if you feel better, continue to take Paroxetine as long as your doctor tells you to do so. How should you take Paroxetine ? Paroxetine is taken once a day, with or without food, usually in the morning. Inform your doctor if you are taking or plan to take any prescription or over the counter drugs, since they may interact unfavorably with Paroxetine. Shake the oral suspension well before using. Paroxetine CR should be swallowed whole; it should not be chewed or crushed. If you miss a dose of Paroxetine Skip the forgotten dose and go back to your regular schedule with the next dose. Do not take a double dose to make up for the one you missed. Storage instructions for Paroxetine Paroxetine tablets and suspension can be stored at room temperature. What side effects may occur when taking Paroxetine ? Side effects of Paroxetine cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine whether it is safe for you to continue taking Paroxetine. During the first 4 to 6 weeks, you may find some side effects less troublesome (nausea and dizziness, for example) than others (dry mouth, drowsiness, and weakness). More common side effects of Paroxetine may include: Abnormal ejaculation, abnormal orgasm, constipation, decreased appetite, decreased sex drive, diarrhea, dizziness, drowsiness, dry mouth, gas, impotence, male and female genital disorders, nausea, nervousness, sleeplessness, sweating, tremor, weakness, vertigo Why should Paroxetine not be prescribed ? Dangerous and even fatal reactions are possible when Paroxetine is combined with thioridazine (Mellaril) or drugs classified as monoamine oxidase (MAO) inhibitors, such as the antidepressants Nardil and Parnate. Never take Paroxetine with any of these medications, or within 2 weeks of starting or stopping use of an MAO inhibitor. You'll also need to avoid Paroxetine if it gives you an allergic reaction. Special warnings about Paroxetine In clinical studies, antidepressants increased the risk of suicidal thinking and behavior in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of Paroxetine or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Paroxetine has not been studied in children or adolescents and is not approved for treating anyone less than 18 years old. Additionally, the progression of major depression is associated with a worsening of symptoms and/or the emergence of suicidal thinking or behavior in both adults and children, whether or not they are taking antidepressants. Individuals being treated with Paroxetine and their caregivers should watch for any change in symptoms or any new symptoms that appear suddenly, especially agitation, anxiety, hostility, panic, restlessness, extreme hyperactivity, and suicidal thinking or behavior, and report them to the doctor immediately. Be especially observant at the beginning of treatment or whenever there is a change in dose. Paroxetine should be used cautiously by people with a history of manic disorders and those with high pressure in the eyes (glaucoma). If you have a history of seizures, make sure your doctor knows about it. Paroxetine should be used with caution in this situation. If you develop seizures once therapy has begun, Paroxetine should be discontinued. If you have a disease or condition that affects your metabolism or blood circulation, make sure your doctor is aware of it. Paroxetine should be used cautiously in this situation. Paroxetine may impair your judgment, thinking, or motor skills. Do not drive, operate dangerous machinery, or participate in any hazardous activity that requires full mental alertness until you are sure Paroxetine is not affecting you in this way. Antidepressants such as Paroxetine could potentially cause stomach bleeding, especially when combined with nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), and ketoprofen (Orudis KT). Consult your doctor before combining Paroxetine with NSAIDs or blood-thinning drugs. It's best to avoid an abrupt discontinuation of Paroxetine therapy. It can lead to symptoms such as dizziness, abnormal dreams, and tingling sensations. To prevent such problems, your doctor will reduce your dose gradually. Possible food and drug interactions when taking Paroxetine Remember that Paroxetine must never be combined with Mellaril or MAO inhibitors such as Nardil and Parnate, or taken within 2 weeks of starting or stopping an MAO inhibitor. If Paroxetine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Paroxetine with any of the following: Alcohol Special information on Paroxetine if you are pregnant or breastfeeding The effects of Paroxetine during pregnancy have not been adequately studied. There have been reports of serious complications in newborns who were exposed to Paroxetine late in the last 3 months of pregnancy. If you are pregnant or plan to become pregnant, inform your doctor immediately. Paroxetine appears in breast milk and could affect a nursing infant. If Paroxetine is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with Paroxetine is finished. Recommended dosages for Paroxetine The following dosages are for adults. The safety and effectiveness of Paroxetine have not been studied in children or adolescents. DEPRESSION The usual starting dose is 20 milligrams a day, taken as a single dose, usually in the morning. At intervals of at least 1 week, your physician may increase your dosage by 10 milligrams a day, up to a maximum of 50 milligrams a day. Paroxetine CR The recommended starting dose is 25 milligrams a day, usually taken in the morning. At intervals of at least 1 week, the dosage may be increased by 12.5 milligrams a day, up to a maximum of 62.5 milligrams a day. OBSESSIVE-COMPULSIVE DISORDER The usual starting dose is 20 milligrams a day, typically taken in the morning. At intervals of at least 1 week, your doctor may increase the dosage by 10 milligrams a day. The recommended long-term dosage is 40 milligrams daily. The maximum is 60 milligrams a day. PANIC DISORDER The usual starting dose is 10 milligrams a day, taken in the morning. At intervals of 1 week or more, the doctor may increase the dose by 10 milligrams a day. The target dose is 40 milligrams daily; dosage should never exceed 60 milligrams. Paroxetine CR The recommended starting dose is 12.5 milligrams a day, usually taken in the morning. At intervals of at least 1 week, the dosage may be increased by 12.5 milligrams a day, up to a maximum of 75 milligrams a day. GENERALIZED ANXIETY DISORDER The recommended dose is 20 milligrams taken once a day, usually in the morning. SOCIAL ANXIETY DISORDER The recommended dose is 20 milligrams taken once a day, usually in the morning. Paroxetine CR The recommended starting dose is 12.5 milligrams a day, usually taken in the morning. At intervals of at least 1 week, the dosage may be increased by 12.5 milligrams a day, up to a maximum of 37.5 milligrams a day. POST-TRAUMATIC STRESS DISORDER The recommended dose is 20 milligrams taken once a day, usually in the morning. PREMENSTRUAL DYSPHORIC DISORDER Paroxetine CR The recommended starting dose is 12.5 milligrams a day, usually taken in the morning. The doctor will instruct the patient to take the dose either every day of the month or only during the 2 weeks before menstruation begins (the luteal phase of their cycle). If needed, the dose can be increased to 25 milligrams a day. DOSAGE ADJUSTMENT For older adults, the weak, and those with severe kidney or liver disease, starting doses are reduced to 10 milligrams daily, and later doses are limited to no more than 40 milligrams a day. Starting doses of Paroxetine CR are limited to 12.5 milligrams daily, and later doses are limited to no more than 50 milligrams a day. Overdosage with Paroxetine Any medication taken in excess can have serious consequences. If you suspect an overdose with Paroxetine, seek medical attention immediately. The symptoms of Paroxetine overdose may include: Coma, dizziness, drowsiness, facial flushing, nausea, sweating, tremor, vomiting
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